Aerobic exercise affects mitochondrial quality control
الموضوعات : فیزیولوژی ورزشی
Faranak Amini
1
,
Mohammad Ali Azarbayjani
2
,
Shahin Riyahi Malayeri
3
,
Lida Moradi
4
1 - Department of Physical Education and Sport Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.
2 - Department of Sports Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
3 - Department of Physical Education and Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran.
4 - Department of Physical Education and Sport Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.
الکلمات المفتاحية: Mitochondrial unfolded protein response, mitochondrial dynamics (fission and fusion), mitophagy, aerobic exercise,
ملخص المقالة :
Mitochondria play a significant role in morphological and physiological aspects of cells according to their known biological role. Any disruption in mitochondrial function weakens cell function and causes many cell diseases. On the other hand, mitochondria health is associated with cellular efficiency and causes health and physical performance. Evidence shows that one of the molecular mechanisms that regular physical activities, especially aerobic exercises, lead to health is mitochondrial health. Aerobic exercise can regulate and control the mitochondrial unfolded protein response (UPRmt), mitochondrial dynamics (fission and fusion) and mitochondrial. It seems that regulation of mRNA expression of proteins responsible for MQC signaling pathways, reduction of inflammation and oxidative stress is one of the mechanisms by which aerobic exercise benefits mitochondria.
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